Fresh analysis reveals that people who discontinue new weight-loss injections like Wegovy and Mounjaro may regain lost weight much more quickly than those who halt conventional diet and exercise programs.
Findings released in a leading medical journal points out that while obese people frequently drop substantial amounts of their total mass while on the medication, the weight returns at an average rate of 0.8 kg per month upon discontinuation.
"People buying these treatments must be cognizant of the danger of rapid weight regain when the therapy ends," stated researcher Dr. Susan Jebb.
This pace of recovery means a return to starting mass in about one and a half years.
Analyzing Approaches
The study, which looked at dozens of studies involving thousands of participants, contrasted the results of the injectable medications with older methods.
Scientists point out that people who shed pounds through dieting usually experience a less rapid creep back—perhaps 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Doctors suggest the way of the jabs is key to understanding the accelerated regain.
These medications copy a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 levels far above than the body's typical production might result in the system to generate a reduced amount of its endogenous hormone, and may also lessen sensitivity to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication means appetite is uncontrolled, making excessive eating much more probable."
A Lifelong Disease?
The NHS advise the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Professionals argue that, due to the high risk of relapse, the therapy is often long-term.
This view is echoed by drug manufacturers, who note that the results "underscore the persistent character of excess weight," comparing it to managing diseases like diabetes.
Patient Accounts
People who have discontinued the jabs report a sudden return of cravings.
"I experienced a switch that goes on and you become ravenous," described an individual.
The struggle is worsened if users have not adopted sustainable lifestyle or habit modifications during treatment.
Growing Interest
Figures indicate that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand remaining high.
- Use is more common among women compared to males.
- The middle-aged demographic shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
Ultimately, experts stress that while GLP-1 drugs are potent agents for shedding pounds, they are not a magic solution and lasting health benefits likely depends on combined lifestyle management.
